The gut brain axis is the two-way biochemical signalling that takes place between the gastrointestinal tract and the central nervous system. The term gut brain axis highlights the role of gut microbiota in these biochemical signalling. Broadly defined, the Gut brain includes the central nervous system, neuroendocrine system, the hypothalamic – pituitary- adrenal axis, sympathetic and parasympathetic arms of autonomic nervous system, the enteric nervous system, vagus nerve, and the gut microbiota1. Grahani roga is the prime disease of gastro-intestinal tract and seen often in day today practice. In our classic grahani is consider as an agni adhistana. Any disturbance in the status of agni lead to grahani roga. Ayurveda described the individuality of mana and shareera and their inseparable and independent relation in formation of disease in grahani roga. Both ayurved and contemporary science accept the fact that for better management and prevention of grahani roga, psychological factors are having a significant role. So, in order to remove diseases from the root, the causative factors should be understood and ruled out completely. In this article an effort is made to understand the role of manasik bhavas in grahani roga.
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